Human Papillomavirus

Virology of HPV  is a double-stranded DNA, non-enveloped capsid virus. Their genome has three functional coding regions. Genome organization is similar for all papillomaviruses which has one strand transcribed. Epidemiology of HPV Infection causes warts, which are noncancerous skin growths known as cutaneous warts. Organization of life cycle can be divided into discrete phases. Initial infection requires access of infectious particles to cells in the basal layer, which for some HPV types is thought to require a break in the stratified epithelium. Toxicity and pathogenesis, Infection by specific HPV types has been linked to the development of cervical carcinoma. HPV infects epithelial cells that undergo terminal differentiation and so encode multiple mechanisms to override the normal regulation of differentiation to produce progeny virions.  The mechanism of HPV  is very complicated as it infects basal epithelial cells, which constitute the onlt cell layer in an epithelium that is actively dividing

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